![]() ![]() The response was monitored by the clinical and radiological improvement. ![]() Therapeutic test was applied for six patients those not responding to empirical with negative results and picture consistent with tuberculosis considered by the team of the work. Paracentesis have been done for one patient that presented with ascitis in Tropical Department of Mansoura Univeristy and ascitic fluid analysis by cell count, albumin level, culture, total protein, Gram stain, ADA, and cytology. GeneXpert MTB/RIF was done for 42 sputum negative patients who were not responding initially on antibiotic empirical therapy.įlexible bronchoscopy and bronchoalveolar lavage for 9 patients (8 in Mansoura Chest Hospital and one in Chest Department of Mansoura University Hospital) who were not responding to empirical therapy with negative sputum ZN and GeneXpert.ĬSF examination for 5 patients those presented by symptoms and signs suggestive for meningitis (persistent headache, vomiting, fever, and neck rigidity) including biochemical, adenosine deaminase (ADA), and microbiological examination. For example, patients with consolidation, empirical therapy was in the form of macrolide with third generation cephalosporin. Tuberculin test TST, sputum ZN staining, and sputum culture on Löwenstein–Jensen medium.Įmpirical therapy had been started for all patients according to the presentation of the patient. Radiological examination: CXR posteroanterior view had been done for all patients.ĬD4 count has been done in Central lab of Cairo for 64 (84.2%) of patients the missing 12 patients were unable to travel Cairo. Ĭlinical examination: General examination and local examination of the chest had been done for all patients. The screening carried out in this study was as follows: current cough, fever, weight loss, or night sweats? Any positive answer was considered as positive screening and the patient was included. Patients on anti-TB drugs or negative screening for sero-positive HIV patients were excluded from the study.Īfter patient acceptance to be included in the study, the patients were subjected to the following:ĭetailed history taking: This included personal history, present history with stress on presence and duration of current cough, fever, weight loss and night sweats, past history of chest diseases or other diseases, family history, and history of contact with TB patient. The study included seropositive HIV patients with a new diagnosis of either pulmonary or extra-pulmonary TB, and also included patients who were presented by symptoms suggestive for tuberculosis, changes in chest X-ray that was not improved by full course of antibiotics or positive tuberculin test ≥ 5 mm. The 76 participants were 62 (81.6%) males and 14 (18.4%) with mean age 36.4☙.5 years, categorized into 2 groups: TB group included 23 patients (30.3%) and non TB included 53 patients (69.7%). This study started by 214 seropositive HIV adult patients from Mansoura Fever Hospital screened by symptoms suggestive of TB only 76 patients of them were included due to presence of positive screening and the other 214 have been excluded because of negative screening for TB. Patients signed their written consents after detailed explanation of the study protocol. The study was registered in clinical trial number (NCT04813666). ![]() Approval from Egyptian Ministry of Health was taken (no.: 1-2016/18). The study was conducted at Mansoura Fever Hospital in collaboration with the Chest Department and Clinical Pathology Department, Mansoura University, Egypt, from January 2015 to October 2016.Įthical approval had been obtained from Medical Research Ethics Committee of Faculty of Medicine, Mansoura University (code no: MD/138). ![]() A diagnostic validity study in which urinary LAM was done in seropositive HIV patients with symptoms suggestive of TB who were included and investigated with battery of tests to reach the final diagnosis. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |